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Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. R&D is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies that matter most. Today, we are at a unique moment in biomedical innovation.

Global Development Lead, Medical Director, Oncology Early Development

ROLE SUMMARY

Support clinical trials and the development strategy for early development assets and lead development programs across multiple functions within Pfizer Oncology, as well as represent the program with the external clinical community.
Develop clinical development plan from first in human clinical trial to proof-of-concept, including assessment of appropriate combinations, as well as evaluation of potential predictive and pharmacodynamics biomarker plans.
To ensure the clinical components of the clinical plans and clinical expertise are provided to project teams, including medical monitoring of clinical trials.
To support projects from Research to Proof of Concept at which point molecule may be handed to the late-stage Oncology Clinical Development team for post-POC (typically phase 3) development.

ROLE RESPONSIBILITIES

Lead, develop and execute strategic development for early development assets.
Oversee early development assets’ development broadly within a specific indication or group of indications. Typically, work on at least two clinical programs and support the development and provide consultation regarding multiple research projects.
Work across the organization and on multifunctional teams responsible for the development of early development assets (including Product Team).
Oversee the development and management of clinical protocols and amendments, investigator brochures, clinical study reports, statistical analysis plan, and regulatory documents.
Provide leadership to early stage clinical scientists on the clinical study team for Early Development Assets, working in a matrix team environment with other clinicians, statisticians, clinical pharmacologists, translational biologists and regulatory specialists. Meet regularly with the Pfizer Oncology group leaders/surrogates across functions to increase mutual awareness and influence of emerging program targets, priorities and status.
Implementation of PK-guided dose escalation, early combination strategies and emerging innovations on all ORD first-in-human clinical trials with input from Oncology Research Unit, Oncology Regulatory Strategy, Clinical Pharmacology and Precision Medicine, Oncology Clinical Development and Operations, Pharm Sci and Product Teams.
Oversee the evaluation of safety, pharmacology, and efficacy data from ongoing and completed studies for early development assets.
Oversee manuscripts, abstracts and presentations for scientific meetings and advisory boards.
Conduct literature reviews and prepare summaries to support clinical development programs.
Medical resource for design and interpretation of clinical and preclinical programs to support existing and new development candidates.
Coordinate regular (at least quarterly and as needed) interactions with preferred clinical trials network and KOL advisory board to objectively consider and implement feedback.
Drive innovations in early clinical development, and the application of translational oncology and precision medicine approaches.
Collaborates with cross-functional leaders and teams to translate early preclinical discovery research into therapeutic candidates.
Coordinates with business development to establish strategic external collaborations and foster new research projects and programs.

BASIC QUALIFICATIONS

MD or MD-PhD with 2+ years of industry experience in oncology drug development is preferred, track record in early phase drug development.
Clinical oncology experience: Board certification in oncology preferred.
Significant industry leadership experience in clinical, translational or basic research in biomedical sciences or one of the disciplines related to drug development.
Understanding of related disciplines (e.g., biostatistics, regulatory, pre-clinical pharmacology, pharmaceutical sciences).
Demonstrated scientific productivity (publications, abstracts, etc.).
Proven scientific writing skills and good communication skills.
Proven leadership skills with ability to defend the clinical plan at governance meetings is essential.
Capacity to adapt to a fast-paced and changing environment.
Demonstrated history of effective leadership; including cross functional and matrixed teams, managing direct reports, and experience in seeking and maintaining alignment with cross-functional leaders.
Demonstrates a passion for helping patients with cancer and for the science of oncology.

I&I Gastroenterology Area Business Manager – Houston, TX

ROLE SUMMARY

This role will report into the RBD and will work with customer– facing and HQ teams across the organization. The ABM will be responsible for the supervision and leadership of 6-10 representatives within the area assigned, sales performance of the business portfolio of products, and business knowledge of the area landscape to assess key stakeholders plus future trends within the business marketplace. This position will require regular in field and virtual coaching and observation of Field Representatives and frequent customer contact as well as the development of a strong, effective partnership with marketing and channel colleagues. The ABM will ensure compliant execution by team members, driving understanding of relevant policies and guidance and advancing a culture of integrity.

Extensive travel will be required.

ROLE RESPONSIBILITIES

Responsible for supervising operations of the district to include hiring, live coaching, virtual coaching, representative development, performance management, and the assignment of key “priority” accounts within the medical community, managing 6-10 representatives.

Develops and implements strategic plans for the District, business plan, and overall responsibility for budgets at District level in alignment with RBD expectations.
Plans, organizes, and monitors performance to achieve the business potential of the District and the RBU
Ensuring effective utilization of promotional material, making valuable contribution to the formulation of Develops and implements strategic plans for the District, business plan, and overall responsibility for budgets at District level in alignment with RBD expectations.
Plans, organizes, and monitors performance to achieve the business potential of the District and the RBU
Proactive data analysis to identify market trends
Collaborates, identifies, & motivates key account development and opportunities that impact regional/national business
Build relationships with customers (including KOLs) and key stakeholders (including members of the District and Region Management Teams, Channel Partners, and other cross-functional partners) and utilizes content appropriately for engagement
Develops external advocates and contributes to advocacy and community engagement (as necessary)
Understands and champions the value of cross-functional collaboration to deliver on customer needs, while ensuring that compliance guardrails are respected by representatives
Coaches’ representatives on seamlessly connecting cross-functional colleagues reactively to address customer needs and how to use digital tools (e.g., digital triage app)
Effectively plan and conduct plan of action and other meetings with District Management Teams, Channel Partners, and other cross-functional partners
Collaborate effectively in an integrated account team
Collaborates, identifies, and partners with Marketing in the development of the key strategies, business imperatives and objectives during the Op Plan process
Retains flexible time management in hybrid environment (e.g., time allocation of F2F v. virtual engagements to meet business objectives to maximize HCP engagement across large(r) geographies)
Works with all members of District to coach and counsel on improvement of performance and skill execution of selling skills, product knowledge, and capabilities needed for successful representative development, including the development of business plans in a hybrid environment
Maintains visibility into planning of individual sales rep
Ensures actions of self and team are fully compliant; has complete understanding of all relevant compliance policies and processes; escalates issues, as necessary, and ensures appropriate commitment to integrity within their team
Implements and upholds District Standards with sales colleagues
Applies situational leadership skills (e.g., knowing when to intervene in virtual environment, aligning coaching to colleague’s developmental level on hybrid engagements)
Employs multiple and interactive methods of coaching across all engagement types (e.g., virtual ‘ride along’, utilization of chat function while shadowing, F2F versus virtual coaching) to build hybrid rep capabilities (incl. hybrid selling skills)
Builds strong team culture, colleague engagement, and morale in a hybrid environment
Promotes a feedback culture and continuous improvement mindset in team to assess quality of customer experience (e.g., uses virtual pulse surveys, team barometers, customer feedback)
Set team goals and hold team members accountable for consistent adherence in a hybrid environment (e.g., time management, technical knowledge, communication, compliance, use of technology, meeting new virtual objectives (e.g., up to 50% virtual engagements)

BASIC QUALIFICATIONS

Bachelor’s Degree required
At least 3-5 years spent in a position with demonstrated leadership across peer and customer groups.
Previous pharmaceutical, biotech, or medical marketing/sales experience preferred
Experience working with key thought leaders or high influence customers in large group practices, hospitals, or managed care organizations preferred.
This position will require travel as needed to develop internal and external relationships.
Valid US driver’s license and a driving record in compliance with company standards
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Postdoctoral Fellow, Biophysics Small Molecule Discovery

ROLE SUMMARY

We are seeking a driven and accomplished postdoctoral fellow to join the Biophysics group within the Pfizer Oncology Research Unit (ORU) in La Jolla, California. This role offers a unique opportunity to collaborate closely with the ADC Chemistry and Tumor Biology teams to advance innovative drug design in oncology.

Under the guidance of experienced mentors with strong academic credentials, the successful candidate will operate with a high degree of independence to characterize drug-protein and protein-protein interactions using both labelled and label-free biophysical methods. Additional characterization may involve biochemical or cellular techniques, contributing to a deeper understanding of molecular mechanisms in cancer therapeutics.

The preferred candidate is motivated, talented, and an innovative scientist, with a passion for tackling complex challenges in both fundamental research and drug discovery. The ideal candidate will have a strong scientific background, demonstrated expertise in biophysical binding methods and protein sciences, and a proven track record of impactful contributions, including publications in leading scientific journals.
This role involves close collaboration with chemists and biologists to deepen our understanding of drug targets and explore novel small-molecule drug modalities. Success in this position requires not only technical excellence but also a collaborative mindset and a drive to contribute to high-impact science.

ROLE RESPONSIBILITIES

Work under minimal supervision to characterize small molecule-protein interactions using label and label-free biophysical methods (SPR, ITC, DSF/ CETSA, TR-FRET)
Regularly communicate data with multi-disciplinary teams as well as provide scientific insights into kinetics and thermodynamics of protein-ligand interactions
Display growing knowledge and understanding of other disciplines relevant to early-stage drug discovery
Identify and integrate emerging biophysical technologies to address challenges associated with novel targets/modalities
Translate results from structural biology experiments to elucidate cell-based mechanisms of action and support the design of small molecules
Present findings in high impact publications or conferences

BASIC QUALIFICATIONS

Ph.D. in Biophysics, Biochemistry, Structural Biology, or closely related field
Successful record of scientific accomplishments evidenced by scientific publications and/or presentations with at least one first-author publication in a peer-reviewed journal
Willingness to make a minimum 2-year commitment
No more than 2 years of post-degree experience.
Demonstrated expertise in both label and label-free biophysical methods (SPR, ITC, DSF, TR-FRET) for characterization of protein-ligand interactions
Hands-on experience in plate-based pharmacology assays
Experience in handling recombinant proteins as tools in biochemical or biophysical assays
Knowledge and understanding in the areas of enzymology, mechanisms of drug action and structural biology
Outstanding publication record reflecting scientific drive and creativity across multiple disciplines
Excellent oral and written communication skills, with advanced interpersonal skills to facilitate knowledge sharing and scientific discussions

Senior Computational Biologist

POSITION SUMMARY

Our Inflammation & Immunology (I&I) unit is dedicated to developing transformative treatments for patients with autoimmune, inflammatory, and immune-mediated diseases, by understanding the pathogenic mechanisms underlying inflammation. As a Senior Computational Biologist in our Systems Immunology group, you will design and implement robust data pipelines that ensure the integrity, scalability, and reproducibility of multi-omics analyses—enabling seamless integration of genomic, transcriptomic, and proteomic data. By applying best practices in data engineering and reproducible research, you will help transform raw biological data into actionable knowledge, accelerating target discovery, biomarker identification, and indication selection, across the drug development pipeline.

RESPONSIBILITIES

Develop and maintain robust workflows for integrating diverse datasets including genomics, transcriptomics, proteomics, spatial omics, and functional genomics studies.
Apply best practices in data management and curation; ensure data integrity, traceability, and version control.
Promote reproducibility and transparency in computational research through standardized methods and documentation.
Communicate methods, analytical results, and interpretation, effectively to collaborators and leadership.
Lead and participate in project teams to mine data for new targets and inform precision medicine strategies.

MINIMUM QUALIFICATIONS

Ph.D. in Computational Biology, Bioinformatics, Biostatistics, or a related field with relevant experience applying quantitative methods to biological questions OR
Master’s degree with at least 3 years of relevant experience applying quantitative methods to biological questions in a pharmaceutical industry setting.
Expertise in computational genetics and multi-omics data analysis, including the integration of genomic, transcriptomic, proteomic, spatial, and other high-dimensional datasets to uncover disease mechanisms and inform therapeutic strategies.
Proficiency in Python and R for data analysis, with working knowledge of Linux-based systems, high-performance computing (HPC) environments, and cloud computing platforms (e.g., AWS, GCP, or Azure) to support scalable and reproducible research workflows.
Demonstrated experience in organizing and managing complex biological datasets using reproducible research practices, including version-controlled workflows, standardized documentation, and adherence to data governance principles to ensure transparency, scalability, and scientific rigor.

PREFERRED QUALIFICATIONS

Background in human biology or medicine, especially in immunology & inflammation.
Familiarity with public or proprietary databases related to inflammatory diseases.
Experience with statistical genetics, population genetics and medical genetics.
Experience with integrating across multi-omics data types, with clinical data and real-world data.
Experience implementing NextFlow Pipelines using AWS Batch.
Experience using PerturbSeq data to infer causal gene regulatory networks, and/or virtual cell foundation models.
Experience with single-cell epigenetics and/or DNA foundation models to integrate locus-to-transcript-to-phenotype relationships at scale.
Strong quantitative skills in statistical and machine learning methods

Gastroenterology Health & Science Sales Specialist – Portland, ME

How You Will Achieve It

ROLE RESPONSIBILITIES

Ability to effectively identify and implement the most efficient virtual/in-person engagement strategies, by customer, to maximize overall effectiveness and impact. Develops and implements effective business and territory call plans and adapts based on self-identified opportunities and insights.

Effectively builds rapport and relationships with customers across virtual and F2F environments; maintains a methodical approach toward call objectives (e.g., clear next steps and appropriate documentation, managing to KPIs); utilizes current digital tools effectively (e.g., Veeva Engage, Zoom, Microsoft Office) as well as adapts quickly to new/beta tools (e.g., digital triage app) for successful customer engagement; leverages analytics to assist with developing insights and next best action plans

Compliantly delivers relevant, targeted messaging utilizing approved materials via customer engagement to drive product demand (ask the HCP to change their prescribing behavior/close sales) and leverages account priorities to drive a positive business outcome; proactively provides insights for the development of new and innovative approved product messaging and resources

Leverages product and disease state knowledge to appropriately educate providers on unbranded and branded product value proposition for relevant patient populations and effectively utilizes approved clinically oriented disease state information, as applicable).

Works effectively with HCPs and directs office staff to plan for customer engagements in multiple formats (e.g., virtual and in-person)

Responsible for strategic deployment of approved Pfizer resources to support provider and patient’s needs (e.g., samples, vouchers, co-pay resources and patient education); works effectively across multiple virtual engagement platforms based on customer preferences/compliance guidelines; able to integrate guidance from management and other support functions (Marketing, Strategy) technical solutions (e.g., content recommendation engines) into pre-call planning; proactive planning and optimization of call environment in multiple locations; able to effectively plan day-to-day work based on personal and customer schedules; collaborate effectively with other Customer-Facing (CF) colleagues and Pfizer Connect team members

Appropriately support patients’ access to Pfizer products by providing relevant information to HCPs on Reimbursement, Patient Assistant Program (PAP), Pfizer hub programs, and Co-Pay Resources.

Present terms of sale of product or existing contract terms where appropriate and with approved language; proactively answer on-label questions; proactively introduce customers to future state Pfizer on-demand portal (Galaxy) with access to appropriate targeted content

Collaborates effectively and compliantly with cross-functional colleagues, including Field Medical, Reimbursement and Key Account Management, to address customer inquiries and advance Pfizer objectives. Able to use triaging protocols and digital apps to create rapid connections with appropriate SMEs to address customer inquiries

Effectively use calendaring tools, leadership goals, and personal insights to address customer priorities calls effectively; and bring insights from customer surveys to leadership to improve model

Must Haves

Bachelor’s Degree OR an associate’s degree with 6+ years of experience; OR high school diploma (or equivalent) with 8+ years of relevant experience.

Minimum of 3 years of previous Pharmaceutical biotech or medical marketing/promotional/sales experience, a promoted position and or developmental role with demonstrated leadership across peer groups with experienced marketing, promotional and sales in a specialized market where third-party reimbursement and service center has been utilized

Have a history of marketing, promotional or sales success, strong territory management skills, outstanding communications skills, as well as demonstrated teamwork, leadership ability and accountability

Must live within 50 miles of the territory

Valid US driver’s license and a driving record in compliance with company standards

Nice-to-Haves

3-5 years specialty marketing/promotional/sales experience

Strong knowledge of disease states, therapeutic areas, and products

Deep knowledge of applicable customers and markets (prescribers/HCPs/institutions/organizations)

Strategic account marketing, promotional, sales and management skills.

Superior marketing, promotional, sales, technical and relationship building skills

Demonstrated track record of assessing account needs and bringing relevant information and resources to drive performance

Demonstrated track record of strong business acumen, problem solving, strategic thinking, data analytical skills and project management skills, as well as excellent planning and prioritization skills

Demonstrated ability to engage, influence and support customers throughout the marketing, promotional and sales process, excellent communication, and interpersonal and leadership skills.

Demonstrated ability to quickly learn and embrace new ways of working in a rapidly changing environment.

Possess the ability to work in a matrix environment and to leverage multiple resources to meet customer needs and deliver results.

Demonstrated track record of strong leadership, cross functional leadership, collaboration, and effective utilization of available resources to drive performance.

Experience working with key thought leaders or high influence customers in large group practices, hospitals, or managed care organizations preferred.

Strong organizational and analytical skills are also required and ability to analyze and draw appropriate conclusions using sales data/call reporting software/applications and able to adapt to Pfizer’s long-range technology adapting and learning to use new technology to deliver in bringing Pfizer information to market