We discovered, developed and produced the first medicines to target the underlying cause of cystic fibrosis (CF) — the result of more than 20 years of research and development. And we haven’t stopped. We continue to investigate additional potential therapies for all people with CF.

Vertex Summer 2025 Intern, Computational Chemistry (Boston, MA)

The Vertex Internship Program offers students the opportunity to learn about the pharmaceutical industry from a hands-on perspective. You will be working closely with and learning from some of the brightest people in the industry. When you join our internship program you should not be surprised to see that our environment is one that is innovative and team oriented, where collaboration is not just a word, and “we are relentless” is in everything we do. Students can expect to be challenged by their project plan, connect with other interns, and feel valued by the Vertex community. Not only will interns learn about their day-to-day tasks through their specific work assignments, but they will interact and have exposure to our organizational leaders and their teams.

Job Summary:

We are seeking a pharmaceutical or pharmacokinetics scientist to join Vertex for an internship experience in the Biopharmaceutics group in the Data and Computational Sciences department. We are looking for an exceptional candidate to assist with benchmarking of physiology-based biopharmaceutics modeling (PBBM) of patients following gastrointestinal surgery. The key tasks for this position include synthesizing literature physiology data on the impacts of gastrointestinal surgery, evaluating the use of PBBMs to predict oral absorption before and after surgery for different types of small molecule drugs, and communication of these results to the project team.

Key Responsibilities:

• The candidate will be expected to work with their mentor to perform a literature review on the physiological impacts of gastrointestinal surgery
• With guidance from their mentor, the candidate will be expected to perform physiology-based biopharmaceutics modeling using GastroPlus software
• The candidate will be expected to clearly communicate trends in the performance of the PBBMs on different types of compounds, such as based on ionizability or solubility
• The candidate must have the ability to work independently and as part of a team
• The candidate must be proactive in seeking guidance when needed
• The candidate will be required to regularly present their progress in formal and informal settings to colleagues
• The candidate will interface with colleagues in other departments, such as Formulation Development or Clinical Development, as needed

Qualifications:

• Master’s Degree (or in progress) or Ph.D. (or in progress) in Pharmaceutical Sciences, Pharmacokinetics, Engineering, Chemistry, or a related field with some experience in computational research
• Proven technical proficiency and demonstrated skill in planning and interpreting modeling work
• Effective communicator (written and verbal), especially within area(s) of expertise
• Exposure to physiology-based biopharmaceutics modeling software (e.g. GastroPlus, SimCYP, gPROMS Formulated Products, PK-Sim) preferred but can be taught
• Permanent legal authorization to work in the United States
• Candidate must be enrolled in an advanced degree program if graduating before May 2025
• Candidate must be available to work full-time, 40 hours per week from May – August 2025

This job posting is for a temporary role with a third-party agency partner that provides services to Vertex.  The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex Spring 2025 Co-op, Real World Analytics (Boston, MA)

Structured under Biometrics, among many other responsibilities, Real World Analytics (RWA) is responsible to in-house database stewardship, providing analytic support to real-world evidence generation, developing dashboard, and maintaining RWA Vnet page. The RWA Co-op will work with RWA team and is responsible for projects that assigned by the team manager. The Co-op will have opportunity to learn and leverage Vertex in-house licensed databases to support team’s research needs and activities, such as explore and investigate methodologies that would apply to real-world evidence generation research projects, as well as put together a tutorial database insight book that will give researchers better understanding of real-world data.

Key Responsibilities:

• Lead the search of methodologies that related to the assigned projects.
• Present the methodologies to the team, implement the methodologies to real-world data, ensure the implementation is transferable to similar datasets.
• Investigate the pro and con of different types of real-world databases, develop database insight book, present the insight book to the team.
• Develop dashboard.

Qualifications:

• Pursuing Master or higher degrees in analytics, public health, epidemiology, data science, or other related subject area.
• Previously experience of handling healthcare data.
• Knowledge of relational database management system (RDBS).
• Hands-on skills of SAS programming, SQL, R, Python, or Power BI.
• Good organizational and written/verbal communication skills.
• Good interpersonal and team player.
• Ability to work effectively in a constantly changing, diverse, and matrix environment.
• Candidate must be enrolled in an advanced degree program if graduating before May 2025
• Candidate must be available to work full-time, 40 hours per week from January – June 2025
• Permanent legal authorization to work in the United States

Program Dates: January – June 2025, Full Time